Microcirculatory function in patients with arterial hypertension, metabolic syndrome and diabetes mellitus

Abstract

Aim. To assess microcirculatory (MC) function in patients with arterial hypertension (AH), AH and metabolic syndrome (MS), AH, MS and Type 2 diabetes mellitus (DM-2).Material and methods. In total, 96 patients with Stage I-II AH and 26 healthy individuals were examined. All patients were divided into three groups: Group I (no clinical or laboratory evidence for MS and DM-2), Group II (MS), Group III (MS and DM-2). In all participants, lipid profile and forearm skin MC (laser Doppler flowmetry method) were assessed.Results. Combination of AH and MS or DM-2 was associated with progressive MC deterioration (increased vasoconstriction, activated passive mechanisms of MC tonus regulation, reduced blood flow effectiveness due to non-capillary bypass, decreased tissue perfusion reserve, prevalent congestive and static MC types).Conclusion. Modern methods of MC assessment in clinical practice provide additional objective information about disease severity and prognosis, which is especially important for patients with MS and DM-2.

Keywords

• arterial hypertension
• metabolic syndrome
• diabetes mellitus
• microcirculation