Case Reports in Gastroenterology (Jul 2016)

Successful Management of Graft Reinfection of HCV Genotype 2 in Living Donor Liver Transplantation from a Hepatitis B Core Antibody-Positive Donor with Sofosbuvir and Ribavirin

  • Reina Sasaki,
  • Tatsuo Kanda,
  • Masayuki Ohtsuka,
  • Shin Yasui,
  • Yuki Haga,
  • Masato Nakamura,
  • Masayuki Yokoyama,
  • Shuang Wu,
  • Shingo Nakamoto,
  • Makoto Arai,
  • Hitoshi Maruyama,
  • Masaru Miyazaki,
  • Osamu Yokosuka

DOI
https://doi.org/10.1159/000447423
Journal volume & issue
Vol. 10, no. 2
pp. 366 – 372

Abstract

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Direct-acting antivirals (DAAs) are relatively safe and highly effective for the eradication of hepatitis C virus (HCV) in liver transplant recipients. In this case study, we present a female with a graft reinfected with HCV genotype 2 who was treated with a combination of sofosbuvir and ribavirin after living donor liver transplantation (LDLT). Because the graft was from a hepatitis B core antibody-positive donor, passive immunization with hyperimmune hepatitis B immunoglobulin (HBIG) and entecavir were also provided to prevent hepatitis B virus (HBV) reactivation. It became clear that the combination of sofosbuvir and ribavirin promptly led to a sustained virologic response and that this combination was safe to treat graft reinfection with HCV genotype 2 after LDLT. Adverse events caused by DAAs were not observed, except for slight anemia. HBIG and entecavir were useful in the prevention of HBV reactivation. In conclusion, the present case indicated that DAA treatment for graft reinfection with HCV is safe and effective in LDLT from hepatitis B core antibody-positive donors.

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