Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE

Christa Caggiano; Barbara Celona; Fleur Garton; Joel Mefford; Brian L. Black; Robert Henderson; Catherine Lomen-Hoerth; Andrew Dahl; Noah Zaitlen

doi:10.1038/s41467-021-22901-x

Nature Communications (May 2021)

Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE

Christa Caggiano,
Barbara Celona,
Fleur Garton,
Joel Mefford,
Brian L. Black,
Robert Henderson,
Catherine Lomen-Hoerth,
Andrew Dahl,
Noah Zaitlen

Affiliations

Christa Caggiano: Bioinformatics Interdepartmental Program, University of California Los Angeles
Barbara Celona: Cardiovascular Research Institute, University of California San Francisco
Fleur Garton: Institute for Molecular Biosciences, University of Queensland
Joel Mefford: Department of Neurology, University of California Los Angeles
Brian L. Black: Cardiovascular Research Institute, University of California San Francisco
Robert Henderson: Department of Neurology, Royal Brisbane and Women’s Hospital
Catherine Lomen-Hoerth: Department of Neurology, University of California San Francisco
Andrew Dahl: Section of Genetic Medicine, Department of Medicine, University of Chicago
Noah Zaitlen: Department of Neurology, University of California Los Angeles

DOI: https://doi.org/10.1038/s41467-021-22901-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Tissue damage and turnover lead to the release of DNA in the blood and can be used to monitor changes in tissue state. Here, the authors developed a tool to accurately estimate the proportion of cell types contributing to cell-free DNA in the blood, with an application to pregnant women and ALS patients.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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