THE USE OF IMMUNOMODULATORS TO PREVENT RESPIRATORY INFECTIONS IN CHILDREN WITH ALLERGIC DISEASES

Abstract

Background: Children with allergic diseases, especially bronchial asthma, are in need of protection from acute respiratory infections, as anti-epidemic measures cannot prevent the spread of influenza; vaccination remains the best means of prevention. Another promising direction in the prevention of acute respiratory infections (ARI) can be immunomodulators of bacterial origin. Objective: Our aim was to study the use of immunomodulators for prevention of respiratory infections with children having allergic diseases. Methods. A comparative analysis of prophylactic efficiency of specific and nonspecific immunoprophylaxis of ARI with children having allergic diseases has been done during three epedemic seasons (2011–2014). Results. For immunization of 335 children aged 3–17 years having a variety of allergic diseases, vaccine (domestic and foreign) in combination with an immunomodulator, and without it have been used. With the help of vaccination, the number of cases of ARI during the whole observation period decreased significantly: 21 (6.3%) children did not have ARI,62 (18.5%) children had ARI once, 252 (75.2%) children — from 1–4 times in a year. Also, significant reduction of frequency of aggravation of the basic disease was observed in all treatment groups. Patients who received only immunomodulator, had significant reduction of both ARI and the basic disease (p <0,05). Conclusion. The use of vaccines in combination with an immunomodulator or without it fully protects children from flu and significantly (1.5 times) reduces prevalence of ARI.

Keywords

• children
• bronchial asthma
• atopic dermatitis
• flu vaccines
• ribosome-proteoglycan complex
• acute respiratory infections