Nature Communications (Feb 2018)
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
- Alison P. Klein,
- Brian M. Wolpin,
- Harvey A. Risch,
- Rachael Z. Stolzenberg-Solomon,
- Evelina Mocci,
- Mingfeng Zhang,
- Federico Canzian,
- Erica J. Childs,
- Jason W. Hoskins,
- Ashley Jermusyk,
- Jun Zhong,
- Fei Chen,
- Demetrius Albanes,
- Gabriella Andreotti,
- Alan A. Arslan,
- Ana Babic,
- William R. Bamlet,
- Laura Beane-Freeman,
- Sonja I. Berndt,
- Amanda Blackford,
- Michael Borges,
- Ayelet Borgida,
- Paige M. Bracci,
- Lauren Brais,
- Paul Brennan,
- Hermann Brenner,
- Bas Bueno-de-Mesquita,
- Julie Buring,
- Daniele Campa,
- Gabriele Capurso,
- Giulia Martina Cavestro,
- Kari G. Chaffee,
- Charles C. Chung,
- Sean Cleary,
- Michelle Cotterchio,
- Frederike Dijk,
- Eric J. Duell,
- Lenka Foretova,
- Charles Fuchs,
- Niccola Funel,
- Steven Gallinger,
- J. Michael M. Gaziano,
- Maria Gazouli,
- Graham G. Giles,
- Edward Giovannucci,
- Michael Goggins,
- Gary E. Goodman,
- Phyllis J. Goodman,
- Thilo Hackert,
- Christopher Haiman,
- Patricia Hartge,
- Manal Hasan,
- Peter Hegyi,
- Kathy J. Helzlsouer,
- Joseph Herman,
- Ivana Holcatova,
- Elizabeth A. Holly,
- Robert Hoover,
- Rayjean J. Hung,
- Eric J. Jacobs,
- Krzysztof Jamroziak,
- Vladimir Janout,
- Rudolf Kaaks,
- Kay-Tee Khaw,
- Eric A. Klein,
- Manolis Kogevinas,
- Charles Kooperberg,
- Matthew H. Kulke,
- Juozas Kupcinskas,
- Robert J. Kurtz,
- Daniel Laheru,
- Stefano Landi,
- Rita T. Lawlor,
- I.-Min Lee,
- Loic LeMarchand,
- Lingeng Lu,
- Núria Malats,
- Andrea Mambrini,
- Satu Mannisto,
- Roger L. Milne,
- Beatrice Mohelníková-Duchoňová,
- Rachel E. Neale,
- John P. Neoptolemos,
- Ann L. Oberg,
- Sara H. Olson,
- Irene Orlow,
- Claudio Pasquali,
- Alpa V. Patel,
- Ulrike Peters,
- Raffaele Pezzilli,
- Miquel Porta,
- Francisco X. Real,
- Nathaniel Rothman,
- Ghislaine Scelo,
- Howard D. Sesso,
- Gianluca Severi,
- Xiao-Ou Shu,
- Debra Silverman,
- Jill P. Smith,
- Pavel Soucek,
- Malin Sund,
- Renata Talar-Wojnarowska,
- Francesca Tavano,
- Mark D. Thornquist,
- Geoffrey S. Tobias,
- Stephen K. Van Den Eeden,
- Yogesh Vashist,
- Kala Visvanathan,
- Pavel Vodicka,
- Jean Wactawski-Wende,
- Zhaoming Wang,
- Nicolas Wentzensen,
- Emily White,
- Herbert Yu,
- Kai Yu,
- Anne Zeleniuch-Jacquotte,
- Wei Zheng,
- Peter Kraft,
- Donghui Li,
- Stephen Chanock,
- Ofure Obazee,
- Gloria M. Petersen,
- Laufey T. Amundadottir
Affiliations
- Alison P. Klein
- Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine
- Brian M. Wolpin
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Harvey A. Risch
- Department of Chronic Disease Epidemiology, Yale School of Public Health
- Rachael Z. Stolzenberg-Solomon
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Evelina Mocci
- Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine
- Mingfeng Zhang
- Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Federico Canzian
- Genomic Epidemiology Group, German Cancer Research Center (DKFZ)
- Erica J. Childs
- Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine
- Jason W. Hoskins
- Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Ashley Jermusyk
- Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Jun Zhong
- Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Fei Chen
- Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine
- Demetrius Albanes
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Gabriella Andreotti
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Alan A. Arslan
- Department of Obstetrics and Gynecology, New York University School of Medicine
- Ana Babic
- Department of Medical Oncology, Dana-Farber Cancer Institute
- William R. Bamlet
- Department of Health Sciences Research, Mayo Clinic College of Medicine
- Laura Beane-Freeman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Sonja I. Berndt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Amanda Blackford
- Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine
- Michael Borges
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine
- Ayelet Borgida
- Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
- Paige M. Bracci
- Department of Epidemiology and Biostatistics, University of California, San Francisco
- Lauren Brais
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Paul Brennan
- International Agency for Research on Cancer (IARC)
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Bas Bueno-de-Mesquita
- Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM)
- Julie Buring
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Daniele Campa
- Department of Biology, University of Pisa
- Gabriele Capurso
- Digestive and Liver Disease Unit, ‘Sapienza’ University of Rome
- Giulia Martina Cavestro
- Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute
- Kari G. Chaffee
- Department of Health Sciences Research, Mayo Clinic College of Medicine
- Charles C. Chung
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Sean Cleary
- Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
- Michelle Cotterchio
- Cancer Care Ontario, University of Toronto
- Frederike Dijk
- Department of Pathology, Academic Medical Center, University of Amsterdam
- Eric J. Duell
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO)
- Lenka Foretova
- Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute
- Charles Fuchs
- Yale Cancer Center
- Niccola Funel
- Department of Translational Research and The New Technologies in Medicine and Surgery, University of Pisa
- Steven Gallinger
- Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
- J. Michael M. Gaziano
- Division of Aging, Brigham and Women’s Hospital
- Maria Gazouli
- Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens
- Graham G. Giles
- Cancer Epidemiology and Intelligence Division, Cancer Council Victoria
- Edward Giovannucci
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Michael Goggins
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine
- Gary E. Goodman
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Phyllis J. Goodman
- SWOG Statistical Center, Fred Hutchinson Cancer Research Center
- Thilo Hackert
- Department of General Surgery, University Hospital Heidelberg
- Christopher Haiman
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California
- Patricia Hartge
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Manal Hasan
- Department of Epidemiology, University of Texas MD Anderson Cancer Center
- Peter Hegyi
- First Department of Medicine, University of Szeged
- Kathy J. Helzlsouer
- Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health
- Joseph Herman
- Department of Radiation Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine
- Ivana Holcatova
- Institute of Public Health and Preventive Medicine, Charles University, 2nd Faculty of Medicine
- Elizabeth A. Holly
- Department of Epidemiology and Biostatistics, University of California, San Francisco
- Robert Hoover
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Rayjean J. Hung
- Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
- Eric J. Jacobs
- Epidemiology Research Program, American Cancer Society
- Krzysztof Jamroziak
- Department of Hematology, Institute of Hematology and Transfusion Medicine
- Vladimir Janout
- Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava
- Rudolf Kaaks
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Kay-Tee Khaw
- School of Clinical Medicine, University of Cambridge
- Eric A. Klein
- Glickman Urological and Kidney Institute, Cleveland Clinic
- Manolis Kogevinas
- ISGlobal, Centre for Research in Environmental Epidemiology (CREAL)
- Charles Kooperberg
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Matthew H. Kulke
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Juozas Kupcinskas
- Department of Gastroenterology, Lithuanian University of Health Sciences
- Robert J. Kurtz
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Daniel Laheru
- Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine
- Stefano Landi
- Department of Biology, University of Pisa
- Rita T. Lawlor
- ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona
- I.-Min Lee
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Loic LeMarchand
- Cancer Epidemiology Program, University of Hawaii Cancer Center
- Lingeng Lu
- Department of Chronic Disease Epidemiology, Yale School of Public Health
- Núria Malats
- Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO)
- Andrea Mambrini
- Oncology Department, ASL1 Massa Carrara
- Satu Mannisto
- Department of Public Health Solutions, National Institute for Health and Welfare
- Roger L. Milne
- Cancer Epidemiology and Intelligence Division, Cancer Council Victoria
- Beatrice Mohelníková-Duchoňová
- Department of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital
- Rachel E. Neale
- Population Health Department, QIMR Berghofer Medical Research Institute
- John P. Neoptolemos
- Department of General Surgery, University of Heidelburg
- Ann L. Oberg
- Department of Health Sciences Research, Mayo Clinic College of Medicine
- Sara H. Olson
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Irene Orlow
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Claudio Pasquali
- Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua
- Alpa V. Patel
- Epidemiology Research Program, American Cancer Society
- Ulrike Peters
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Raffaele Pezzilli
- Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant’Orsola-Malpighi Hospital
- Miquel Porta
- CIBER Epidemiología y Salud Pública (CIBERESP)
- Francisco X. Real
- CIBERONC
- Nathaniel Rothman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Ghislaine Scelo
- International Agency for Research on Cancer (IARC)
- Howard D. Sesso
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Gianluca Severi
- Cancer Epidemiology and Intelligence Division, Cancer Council Victoria
- Xiao-Ou Shu
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Debra Silverman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Jill P. Smith
- Department of Medicine, Georgetown University
- Pavel Soucek
- Laboratory for Pharmacogenomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University
- Malin Sund
- Department of Surgical and Perioperative Sciences, Umeå University
- Renata Talar-Wojnarowska
- Department of Digestive Tract Diseases, Medical University of Łodz
- Francesca Tavano
- Division of Gastroenterology and Research Laboratory, IRCCS Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”
- Mark D. Thornquist
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Geoffrey S. Tobias
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Stephen K. Van Den Eeden
- Division of Research, Kaiser Permanente Northern California
- Yogesh Vashist
- Department of General, Visceral and Thoracic Surgery, University Hamburg-Eppendorf
- Kala Visvanathan
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Pavel Vodicka
- Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic
- Jean Wactawski-Wende
- Department of Epidemiology and Environmental Health, University at Buffalo
- Zhaoming Wang
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Nicolas Wentzensen
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Emily White
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Herbert Yu
- Cancer Epidemiology Program, University of Hawaii Cancer Center
- Kai Yu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Anne Zeleniuch-Jacquotte
- Department of Population Health, New York University School of Medicine
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Peter Kraft
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Donghui Li
- Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center
- Stephen Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Ofure Obazee
- Genomic Epidemiology Group, German Cancer Research Center (DKFZ)
- Gloria M. Petersen
- Department of Health Sciences Research, Mayo Clinic College of Medicine
- Laufey T. Amundadottir
- Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-018-02942-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Genetic variants associated with susceptibility to pancreatic cancer have been identified using genome wide association studies (GWAS). Here, the authors combine data from over 9000 patients and perform a meta-analysis to identify five novel loci linked to pancreatic cancer.
