Hydrogel oxygen reservoirs increase functional integration of neural stem cell grafts by meeting metabolic demands

Y. Wang; E. R. Zoneff; J. W. Thomas; N. Hong; L. L. Tan; D. J. McGillivray; A. W. Perriman; K. C. L. Law; L. H. Thompson; N. Moriarty; C. L. Parish; R. J. Williams; C. J. Jackson; D. R. Nisbet

doi:10.1038/s41467-023-36133-8

Nature Communications (Jan 2023)

Hydrogel oxygen reservoirs increase functional integration of neural stem cell grafts by meeting metabolic demands

Y. Wang,
E. R. Zoneff,
J. W. Thomas,
N. Hong,
L. L. Tan,
D. J. McGillivray,
A. W. Perriman,
K. C. L. Law,
L. H. Thompson,
N. Moriarty,
C. L. Parish,
R. J. Williams,
C. J. Jackson,
D. R. Nisbet

Affiliations

Y. Wang: Laboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, Australian National University
E. R. Zoneff: Laboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, Australian National University
J. W. Thomas: Laboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, Australian National University
N. Hong: Research School of Chemistry, Australian National University
L. L. Tan: Research School of Chemistry, Australian National University
D. J. McGillivray: School of Chemical Sciences, University of Auckland
A. W. Perriman: Research School of Chemistry, Australian National University
K. C. L. Law: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne
L. H. Thompson: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne
N. Moriarty: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne
C. L. Parish: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne
R. J. Williams: Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University
C. J. Jackson: Research School of Chemistry, Australian National University
D. R. Nisbet: Laboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, Australian National University

DOI: https://doi.org/10.1038/s41467-023-36133-8
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 11

Abstract

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Injectable biomimetic hydrogels hold significant promise for tissue engineering applications. Here, the authors present a hybrid myoglobin:peptide hydrogel to overcome a critical oxygen shortage following neural stem cell transplantation, thus increasing cell survival and integration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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