Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate

Veronika Kovač; Ivana Kmetič; Teuta Murati; Marina Miletić; Lidija Barišić

doi:10.5562/cca2992

Croatica Chemica Acta (Sep 2016)

Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate

Veronika Kovač,
Ivana Kmetič,
Teuta Murati,
Marina Miletić,
Lidija Barišić

Affiliations

Veronika Kovač: Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
Ivana Kmetič: Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
Teuta Murati: Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
Marina Miletić: Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
Lidija Barišić: Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia

DOI: https://doi.org/10.5562/cca2992
Journal volume & issue: Vol. 89, no. 3
pp. 339 – 343

Abstract

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The bioorganometallic III containing trimethylene chain between ferrocene and resveratrol (3,5,4'-trihydroxystilbene, RSV) moieties connected via ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR (1H, 13C, COSY, NOESY, HMBC) spectroscopy, ESI-MS and HRMS. The RSV and ferrocene-RSV conjugate III were screened in vitro for their inhibitory effects against proliferation of hepatoblastoma (Hep G2) cells by MTT assay. Also, possible cytotoxicity towards normal ovary cells (CHO-K1) was evaluated. The obtained data revealed profound effects in biological/cytotoxic activity of III vs. RSV in Hep G2 cell line. Lower cytotoxicity of III was observed in normal ovary cells as compared to hepatoblastoma cells. This work is licensed under a Creative Commons Attribution 4.0 International License.

Published in Croatica Chemica Acta

ISSN: 0011-1643 (Print); 1334-417X (Online)
Publisher: Croatian Chemical Society
Country of publisher: Croatia
LCC subjects: Science: Chemistry
Website: http://cca.hkd.hr/

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