PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis

Shasha Yin; Liu Liu; Charles Brobbey; Viswanathan Palanisamy; Lauren E. Ball; Shaun K. Olsen; Michael C. Ostrowski; Wenjian Gan

doi:10.1038/s41467-021-23833-2

Nature Communications (Jun 2021)

PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis

Shasha Yin,
Liu Liu,
Charles Brobbey,
Viswanathan Palanisamy,
Lauren E. Ball,
Shaun K. Olsen,
Michael C. Ostrowski,
Wenjian Gan

Affiliations

Shasha Yin: Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
Liu Liu: Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
Charles Brobbey: Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
Viswanathan Palanisamy: Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
Lauren E. Ball: Department of Cell and Molecular Pharmacology, and Experimental Therapeutics, Medical University of South Carolina
Shaun K. Olsen: Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio
Michael C. Ostrowski: Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
Wenjian Gan: Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina

DOI: https://doi.org/10.1038/s41467-021-23833-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Arginine methylation has been reported to regulate AKT-associated signalling. Here, the authors show that PRMT5-mediated arginine methylation promotes AKT activity and induces tumourigenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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