Acquired and Inherited Zinc Deficiency-Related Diseases in Children: A Case Series and a Narrative Review

Tommaso Bellini; Marta Bustaffa; Barbara Tubino; Benedetta Giordano; Clelia Formigoni; Elena Fueri; Federica Casabona; Barbara Vanorio; Andrea Pastorino; Astrid Herzum; Caterina Matucci-Cerinic; Serena Arrigo; Gianmaria Viglizzo; Emanuela Piccotti

doi:10.3390/pediatric16030051

Pediatric Reports (Jul 2024)

Acquired and Inherited Zinc Deficiency-Related Diseases in Children: A Case Series and a Narrative Review

Tommaso Bellini,
Marta Bustaffa,
Barbara Tubino,
Benedetta Giordano,
Clelia Formigoni,
Elena Fueri,
Federica Casabona,
Barbara Vanorio,
Andrea Pastorino,
Astrid Herzum,
Caterina Matucci-Cerinic,
Serena Arrigo,
Gianmaria Viglizzo,
Emanuela Piccotti

Affiliations

Tommaso Bellini: Pediatric Emergency Room and Emergency Medicine Unit, Emergency Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy
Marta Bustaffa: Pediatric Emergency Room and Emergency Medicine Unit, Emergency Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy
Barbara Tubino: Pediatric Emergency Room and Emergency Medicine Unit, Emergency Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy
Benedetta Giordano: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal, and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy
Clelia Formigoni: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal, and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy
Elena Fueri: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal, and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy
Federica Casabona: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal, and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy
Barbara Vanorio: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal, and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy
Andrea Pastorino: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal, and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy
Astrid Herzum: Dermatology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy
Caterina Matucci-Cerinic: Reumatology and Autoinflammatory Diseases Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy
Serena Arrigo: Gastroenterology and Digestive Endoscopy Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy
Gianmaria Viglizzo: Dermatology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy
Emanuela Piccotti: Pediatric Emergency Room and Emergency Medicine Unit, Emergency Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy

DOI: https://doi.org/10.3390/pediatric16030051
Journal volume & issue: Vol. 16, no. 3
pp. 602 – 617

Abstract

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Zinc deficiency is a significant global health concern among children, manifesting in various acquired and inherited conditions. This comprehensive overview of acquired and inherited zinc deficiency-related diseases in children aimed to explore the clinical presentations, diagnostic challenges, and management strategies associated with these conditions. This case series elucidates the diverse clinical manifestations of zinc deficiency in pediatric patients, ranging from dermatitis and growth retardation to immune dysregulation and neurological abnormalities, and discusses the underlying genetic mechanisms, clinical phenotypes, and therapeutic interventions. The complexity of zinc deficiency-related diseases in children underscores the need for a multidisciplinary approach involving pediatricians, dermatologists, geneticists, and nutritionists to optimize patient care and outcomes.

Published in Pediatric Reports

ISSN: 2036-749X (Print); 2036-7503 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: https://www.mdpi.com/journal/pediatrrep

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