The causes of development and methods of correction of post-transplant diabetes mellitus

Abstract

The Review deals with the problem of post-transplant diabetes mellitus as one of the complications after kidney transplantation. The authors have reviewed the clinical and experimental studies, described the mechanisms of immunosuppressive drug effects on carbohydrate metabolism and the risk factors for posttransplant diabetes mellitus and its complications, discussed the main drugs used for the carbohydrate metabolism correction and their mechanisms of action.

Keywords

• post-transplant diabetes mellitus
• diabetes mellitus
• impaired glucose tolerance
• tacrolimus
• cadaveric kidney allotransplantation
• oral hypoglycemic drugs