Clinical and Translational Medicine (Aug 2023)

mRNA vaccine in cancer therapy: Current advance and future outlook

  • Youhuai Li,
  • Mina Wang,
  • Xueqiang Peng,
  • Yingying Yang,
  • Qishuang Chen,
  • Jiaxing Liu,
  • Qing She,
  • Jichao Tan,
  • Chuyuan Lou,
  • Zehuan Liao,
  • Xuexin Li

DOI
https://doi.org/10.1002/ctm2.1384
Journal volume & issue
Vol. 13, no. 8
pp. n/a – n/a

Abstract

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Abstract Messenger ribonucleic acid (mRNA) vaccines are a relatively new class of vaccines that have shown great promise in the immunotherapy of a wide variety of infectious diseases and cancer. In the past 2 years, SARS‐CoV‐2 mRNA vaccines have contributed tremendously against SARS‐CoV2, which has prompted the arrival of the mRNA vaccine research boom, especially in the research of cancer vaccines. Compared with conventional cancer vaccines, mRNA vaccines have significant advantages, including efficient production of protective immune responses, relatively low side effects and lower cost of acquisition. In this review, we elaborated on the development of cancer vaccines and mRNA cancer vaccines, as well as the potential biological mechanisms of mRNA cancer vaccines and the latest progress in various tumour treatments, and discussed the challenges and future directions for the field.

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