Nature Communications (Feb 2021)

Complete and cooperative in vitro assembly of computationally designed self-assembling protein nanomaterials

  • Adam J. Wargacki,
  • Tobias P. Wörner,
  • Michiel van de Waterbeemd,
  • Daniel Ellis,
  • Albert J. R. Heck,
  • Neil P. King

DOI
https://doi.org/10.1038/s41467-021-21251-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Recent advances in computational methods have enabled the predictive design of self-assembling protein nanomaterials with atomic-level accuracy. Here authors investigate the assembly of two computationally designed, 120-subunit icosahedral complexes and find that assembly of each material from its two constituent protein building blocks was highly cooperative.