Molecules (Oct 2005)

Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones

  • Patrice Vanelle,
  • Michel P. Crozet,
  • Pascal George,
  • Maxime D. Crozet

DOI
https://doi.org/10.3390/10101318
Journal volume & issue
Vol. 10, no. 10
pp. 1318 – 1324

Abstract

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Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives are reported. These reactions afforded the target bicyclic 2-pyridones in good to excellent yields.

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