T cell receptor recognition of CD1b presenting a mycobacterial glycolipid

Stephanie Gras; Ildiko Van Rhijn; Adam Shahine; Tan-Yun Cheng; Mugdha Bhati; Li Lynn Tan; Hanim Halim; Kathryn D. Tuttle; Laurent Gapin; Jérôme Le Nours; D. Branch Moody; Jamie Rossjohn

doi:10.1038/ncomms13257

Nature Communications (Oct 2016)

T cell receptor recognition of CD1b presenting a mycobacterial glycolipid

Stephanie Gras,
Ildiko Van Rhijn,
Adam Shahine,
Tan-Yun Cheng,
Mugdha Bhati,
Li Lynn Tan,
Hanim Halim,
Kathryn D. Tuttle,
Laurent Gapin,
Jérôme Le Nours,
D. Branch Moody,
Jamie Rossjohn

Affiliations

Stephanie Gras: Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
Ildiko Van Rhijn: Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School
Adam Shahine: Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
Tan-Yun Cheng: Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School
Mugdha Bhati: Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
Li Lynn Tan: Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
Hanim Halim: Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
Kathryn D. Tuttle: Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus and National Jewish Health
Laurent Gapin: Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus and National Jewish Health
Jérôme Le Nours: Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
D. Branch Moody: Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School
Jamie Rossjohn: Infection and Immunity Program, Biomedicine Discovery Institute, Monash University

DOI: https://doi.org/10.1038/ncomms13257
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Germline-encoded mycolyl lipid-reactive (GEM) T cells recognize CD1b proteins presenting mycobacterial mycolates via their T-cell receptors (TCRs). Here, the authors present the structure of this interaction and provide a molecular basis for the co-recognition of CD1b and a mycobacterial glycolipid.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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