[68Ga]Ga-FAPI PET/CT in brain tumors: comparison with [18F]F-FDG PET/CT

Ya Liu; Ya Liu; Ya Liu; Haoyuan Ding; Haoyuan Ding; Haoyuan Ding; Jianpeng Cao; Guangfu Liu; Guangfu Liu; Guangfu Liu; Yue Chen; Yue Chen; Yue Chen; Zhanwen Huang; Zhanwen Huang; Zhanwen Huang

doi:10.3389/fonc.2024.1436009

Frontiers in Oncology (Sep 2024)

[68Ga]Ga-FAPI PET/CT in brain tumors: comparison with [18F]F-FDG PET/CT

Ya Liu,
Ya Liu,
Ya Liu,
Haoyuan Ding,
Haoyuan Ding,
Haoyuan Ding,
Jianpeng Cao,
Guangfu Liu,
Guangfu Liu,
Guangfu Liu,
Yue Chen,
Yue Chen,
Yue Chen,
Zhanwen Huang,
Zhanwen Huang,
Zhanwen Huang

Affiliations

Ya Liu: Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
Ya Liu: Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, China
Ya Liu: Institute of Nuclear Medicine, Southwest Medical University, Luzhou, Sichuan, China
Haoyuan Ding: Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
Haoyuan Ding: Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, China
Haoyuan Ding: Institute of Nuclear Medicine, Southwest Medical University, Luzhou, Sichuan, China
Jianpeng Cao: Department of Nuclear Medicine, Second Affiliated Hospital of Chengdu Medical College (China National Nuclear Corporation 416 Hospital), Chengdu, Sichuan, China
Guangfu Liu: Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
Guangfu Liu: Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, China
Guangfu Liu: Institute of Nuclear Medicine, Southwest Medical University, Luzhou, Sichuan, China
Yue Chen: Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
Yue Chen: Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, China
Yue Chen: Institute of Nuclear Medicine, Southwest Medical University, Luzhou, Sichuan, China
Zhanwen Huang: Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
Zhanwen Huang: Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, China
Zhanwen Huang: Institute of Nuclear Medicine, Southwest Medical University, Luzhou, Sichuan, China

DOI: https://doi.org/10.3389/fonc.2024.1436009
Journal volume & issue: Vol. 14

Abstract

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PurposeTo investigate the feasibility of [68Ga]Ga-FAPI PET/CT in brain tumor imaging and to compare it with [18F]F-FDG PET/CT.Methods25 patients with MRI-suspected brain tumors were included in the study. They underwent whole body [18F]F-FDG PET/CT and [68Ga]Ga-FAPI PET/CT and brain scans. The target-to-background ratio (TBR) of brain tumors was calculated with the background of surrounding normal brain tissues uptake. The SUVmax and TBR of [18F]F-FDG PET/CT and [68Ga]Ga-FAPI PET/CT were compared. Additionally, the correlation between the uptake of the tracer by lesions with the greatest diameter of the lesion, the breadth of the oedema band, and the enhancement scores of the MRI enhancement scans was analyzed.Result[68Ga]Ga-FAPI PET/CT was superior to [18F]F-FDG PET/CT for lesion detection, especially for brain metastases. Among gliomas, only high-grade gliomas uptake [68Ga]Ga-FAPI. Compared with [18F]F-FDG PET/CT, [68Ga]Ga-FAPI PET/CT had a lower SUVmax but a significantly better TBR. On [68Ga]Ga-FAPI PET/CT, the TBR may be associated with brain tumor blood-brain barrier disruption.Conclusions[68Ga]Ga-FAPI PET/CT is a promising imaging tool for the assessment of brain tumors. Lack of physiological uptake of [68Ga]Ga-FAPI in normal brain parenchyma results in high TBR values, leading to better visualization of lesions and contributing to subsequent targeted therapy studies.Advances in knowledgeClinical utility of [68Ga]Ga-FAPI PET/CT in brain tumors remains unclear, and there aren’t many similar studies in the literature. We evaluated the role of [68Ga]Ga-FAPI PET/CT in diagnosing brain tumors.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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