Frontiers in Immunology (May 2024)
Pathogenic role of different phenotypes of immune cells in airway allergic diseases: a study based on Mendelian randomization
- Zhihan Xu,
- Zhihan Xu,
- Zhihan Xu,
- Zhihan Xu,
- Ren Li,
- Ren Li,
- Leigang Wang,
- Yisha Wu,
- Yisha Wu,
- Yisha Wu,
- Yisha Wu,
- Yuhe Tian,
- Yuhe Tian,
- Yuhe Tian,
- Yuhe Tian,
- Yilin Su,
- Yilin Su,
- Yilin Su,
- Yilin Su,
- Yuqiang Ma,
- Yuqiang Ma,
- Yuqiang Ma,
- Yuqiang Ma,
- Ruiying Li,
- Ruiying Li,
- Ruiying Li,
- Ruiying Li,
- Yao Wei,
- Yao Wei,
- Yao Wei,
- Yao Wei,
- Chen Zhang,
- Chen Zhang,
- Chen Zhang,
- Chen Zhang,
- Shikai Han,
- Shikai Han,
- Shikai Han,
- Shikai Han,
- Siyu Duan,
- Siyu Duan,
- Siyu Duan,
- Siyu Duan,
- Haiyi Peng,
- Haiyi Peng,
- Haiyi Peng,
- Haiyi Peng,
- Jinmei Xue,
- Jinmei Xue,
- Jinmei Xue,
- Jinmei Xue
Affiliations
- Zhihan Xu
- Department of Otolaryngology, Head and Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Zhihan Xu
- Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Zhihan Xu
- Shanxi Airway Inflammatory Diseases Neuroimmunity Laboratory, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Zhihan Xu
- Shanxi Medical University, Taiyuan, Shanxi, China
- Ren Li
- Shanxi Medical University, Taiyuan, Shanxi, China
- Ren Li
- Department of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China
- Leigang Wang
- Shanxi Medical University, Taiyuan, Shanxi, China
- Yisha Wu
- Department of Otolaryngology, Head and Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yisha Wu
- Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yisha Wu
- Shanxi Airway Inflammatory Diseases Neuroimmunity Laboratory, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yisha Wu
- Shanxi Medical University, Taiyuan, Shanxi, China
- Yuhe Tian
- Department of Otolaryngology, Head and Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yuhe Tian
- Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yuhe Tian
- Shanxi Airway Inflammatory Diseases Neuroimmunity Laboratory, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yuhe Tian
- Shanxi Medical University, Taiyuan, Shanxi, China
- Yilin Su
- Department of Otolaryngology, Head and Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yilin Su
- Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yilin Su
- Shanxi Airway Inflammatory Diseases Neuroimmunity Laboratory, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yilin Su
- Shanxi Medical University, Taiyuan, Shanxi, China
- Yuqiang Ma
- Department of Otolaryngology, Head and Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yuqiang Ma
- Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yuqiang Ma
- Shanxi Airway Inflammatory Diseases Neuroimmunity Laboratory, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yuqiang Ma
- Shanxi Medical University, Taiyuan, Shanxi, China
- Ruiying Li
- Department of Otolaryngology, Head and Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Ruiying Li
- Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Ruiying Li
- Shanxi Airway Inflammatory Diseases Neuroimmunity Laboratory, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Ruiying Li
- Shanxi Medical University, Taiyuan, Shanxi, China
- Yao Wei
- Department of Otolaryngology, Head and Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yao Wei
- Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yao Wei
- Shanxi Airway Inflammatory Diseases Neuroimmunity Laboratory, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Yao Wei
- Shanxi Medical University, Taiyuan, Shanxi, China
- Chen Zhang
- Department of Otolaryngology, Head and Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Chen Zhang
- Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Chen Zhang
- Shanxi Airway Inflammatory Diseases Neuroimmunity Laboratory, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Chen Zhang
- Shanxi Medical University, Taiyuan, Shanxi, China
- Shikai Han
- Department of Otolaryngology, Head and Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Shikai Han
- Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Shikai Han
- Shanxi Airway Inflammatory Diseases Neuroimmunity Laboratory, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Shikai Han
- Shanxi Medical University, Taiyuan, Shanxi, China
- Siyu Duan
- Department of Otolaryngology, Head and Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Siyu Duan
- Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Siyu Duan
- Shanxi Airway Inflammatory Diseases Neuroimmunity Laboratory, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Siyu Duan
- Shanxi Medical University, Taiyuan, Shanxi, China
- Haiyi Peng
- Department of Otolaryngology, Head and Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Haiyi Peng
- Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Haiyi Peng
- Shanxi Airway Inflammatory Diseases Neuroimmunity Laboratory, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Haiyi Peng
- Shanxi Medical University, Taiyuan, Shanxi, China
- Jinmei Xue
- Department of Otolaryngology, Head and Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Jinmei Xue
- Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Jinmei Xue
- Shanxi Airway Inflammatory Diseases Neuroimmunity Laboratory, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China
- Jinmei Xue
- Shanxi Medical University, Taiyuan, Shanxi, China
- DOI
- https://doi.org/10.3389/fimmu.2024.1349470
- Journal volume & issue
-
Vol. 15
Abstract
BackgroundAirway allergic disease (AAD) is a class of autoimmune diseases with predominantly Th2-type inflammation, mainly including allergic rhinitis (AR), allergic asthma (AS), and chronic sinusitis (CRS). There are very complex regulatory mechanisms between immune cells and AAD; however, previous reports found that the functions of the same immune cells in AAD are not identical.ObjectiveThe aim of this study was to explore the causal relationship between different phenotypic immune cells and their association with AAD.MethodUtilizing the publicly available Genome-Wide Association Studies (GWAS) database, this study conducted a bidirectional Mendelian randomization (MR) to assess the causal relationship between immune cells of 731 different immunophenotypes and AAD. The primary assessment methods included inverse variance weighting, weighted median, and MR Egger. Additionally, sensitivity analyses such as MR-PRESSO, leave-one-out, and scatter plots were employed to eliminate the interference of heterogeneity and pleiotropy, ensuring the stability of the causal inference.ResultA total of 38 immune cells with different immunophenotypes were found to be positively and causally associated with AR, of which 26 were protective factors and 12 were risk factors. Positive associations were found between 33 immune cells and AS, of which 14 were protective factors and 19 were risk factors, as well as between 39 immune cells and CRS, of which 22 were protective factors and 17 were risk factors. Finally, the results of all relevant immune cells for the three diseases were taken and intersected, and it was found that CD3 on CD39+-activated Treg (IVWAR = 0.001, IVWCRS = 0.043, IVWAS = 0.027) may be the key immune cell that inhibits the development of AAD (ORAR = 0.940, ORAS = 0.967, ORCRS = 0.976).ConclusionThis study reveals that different immune phenotypes of immune cells are closely related to AAD at the genetic level, which provides a theoretical basis for future clinical studies.
Keywords
