Passerini-type reaction of boronic acids enables α-hydroxyketones synthesis

Kai Yang; Feng Zhang; Tongchang Fang; Chaokun Li; Wangyang Li; Qiuling Song

doi:10.1038/s41467-020-20727-7

Nature Communications (Jan 2021)

Passerini-type reaction of boronic acids enables α-hydroxyketones synthesis

Kai Yang,
Feng Zhang,
Tongchang Fang,
Chaokun Li,
Wangyang Li,
Qiuling Song

Affiliations

Kai Yang: Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University
Feng Zhang: Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University
Tongchang Fang: Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University
Chaokun Li: Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University
Wangyang Li: Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University
Qiuling Song: Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University

DOI: https://doi.org/10.1038/s41467-020-20727-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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Multicomponent reactions enable the rapid construction of diverse molecular scaffolds with modularity and step economy. In this work, the authors report the use of boronic acids as carbon nucleophiles in a Passerini-type three-component coupling reaction towards an expanded inventory of α-hydroxyketones.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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