Dominant Bacterial Phyla from the Human Gut Show Widespread Ability To Transform and Conjugate Bile Acids

L. N. Lucas; K. Barrett; R. L. Kerby; Q. Zhang; L. E. Cattaneo; D. Stevenson; F. E. Rey; D. Amador-Noguez

doi:10.1128/mSystems.00805-21

mSystems (Aug 2021)

Dominant Bacterial Phyla from the Human Gut Show Widespread Ability To Transform and Conjugate Bile Acids

L. N. Lucas,
K. Barrett,
R. L. Kerby,
Q. Zhang,
L. E. Cattaneo,
D. Stevenson,
F. E. Rey,
D. Amador-Noguez

Affiliations

L. N. Lucas: Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin, USA
K. Barrett: Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin, USA
R. L. Kerby: Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin, USA
Q. Zhang: Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin, USA
L. E. Cattaneo: Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin, USA
D. Stevenson: Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin, USA
F. E. Rey: Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin, USA
D. Amador-Noguez: ORCiD; Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin, USA

DOI: https://doi.org/10.1128/mSystems.00805-21
Journal volume & issue: Vol. 6, no. 4

Abstract

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Our current knowledge regarding microbial bile acid transformations comes primarily from biochemical studies on a relatively small number of species or from bioinformatic predictions that rely on homology to known bile acid-transforming enzyme sequences. Therefore, much remains to be learned regarding the variety of bile acid transformations and their representation across gut microbial species.

Published in mSystems

ISSN: 2379-5077 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msystems

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