STRUCTURAL AND METABOLIC CHARACTERISTICS OF COMPENSATORY-ADAPTIVE PROCESSES IN THE HEPATOBILIARY SYSTEM WITH ACETATE GASTRIC AND EXPOSURE TO PESTICIDES

Abstract

Abstract. Aim. To study the structural and metabolic features of the hepatobiliary system for chronic oral exposure to pesticides in combination with acetate gastric ulcer. Methods. After playing acetate stomach ulcers spent histomorphologically and histoenzymatic research cryostatic and paraffin tissue sections of the liver of experimental and control animals. Set response to succinate dehydroge nase, lactate dehydrogenase, which is glitserofosfatdegidrogenazy, nicotineinduced diaphorase, monoamine oxi dase, acid and alkaline phosphatase; determined the content of glycogen and RNA in the liver with subsequent com puter flow cytometric evaluation. Results. When injecting pesticides at 1 exposure limit values (ELV) to animals there increase metabolic and protec tiveadaptive processes both in ulcer border zone and in remote fraction of the liver. Increasing doses of pesticides up to 50 ELV and above cause aggressive course of ulcer with penetration into the liver and development of second ary hepatitis, hepatosclerosis and dysfunction of the hepatobiliary system. Main conclusions. When combined pathology with gastric ulcers modeling (OkabePfeiffer) and chronic oral expo sure of hexachlorocyclohexane, CuSO4, chlorophos pathomorphological changes in the liver are caused by both dose of pesticides and ulcers morphogenesis. The most toxic for the liver from the studied pesticides is hexachloro cyclohexane.

Keywords

• liver
• stomach ulcer
• pesticides