Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase

Abstract

Prior to initiate energy-consuming processes, such as DNA replication or cell division, cells need to evaluate their metabolic status. We have recently identified and characterized a new connection between metabolism and cell division in the α-proteobacterium Caulobacter crescentus. We showed that an NAD-dependent glutamate dehydrogenase (GdhZ) coordinates growth with cell division according to its enzymatic activity. Here we report the conserved role of GdhZ in controlling cell division in another α-proteobacterium, the facultative intracellular pathogen Brucella abortus. We also discuss the importance of amino acids as a main carbon source for α-proteobacteria.

Keywords

• α-proteobacteria
• Brucella
• Caulobacter
• cytokinesis
• cell division
• FstZ
• glutamate dehydrogenase
• GdhZ