Different macaque brain network remodeling after spinal cord injury and NT3 treatment

Ting Feng; Can Zhao; Jia-Sheng Rao; Xiao-Jun Guo; Shu-Sheng Bao; Le-Wei He; Wen Zhao; Zuxiang Liu; Zhao-Yang Yang; Xiao-Guang Li

iScience (Jun 2023)

Different macaque brain network remodeling after spinal cord injury and NT3 treatment

Ting Feng,
Can Zhao,
Jia-Sheng Rao,
Xiao-Jun Guo,
Shu-Sheng Bao,
Le-Wei He,
Wen Zhao,
Zuxiang Liu,
Zhao-Yang Yang,
Xiao-Guang Li

Affiliations

Ting Feng: School of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China
Can Zhao: Institute of Rehabilitation Engineering, China Rehabilitation Science Institute, Beijing, PR China
Jia-Sheng Rao: School of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China; Corresponding author
Xiao-Jun Guo: School of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China
Shu-Sheng Bao: School of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China
Le-Wei He: School of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China
Wen Zhao: Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, PR China
Zuxiang Liu: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China; Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, PR China; Department of Biology, College of Life Sciences, University of Chinese Academy of Sciences, Beijing, PR China; Corresponding author
Zhao-Yang Yang: Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, PR China; Corresponding author
Xiao-Guang Li: School of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China; Corresponding author

Journal volume & issue: Vol. 26, no. 6
p. 106784

Abstract

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Summary: Graph theory-based analysis describes the brain as a complex network. Only a few studies have examined modular composition and functional connectivity (FC) between modules in patients with spinal cord injury (SCI). Little is known about the longitudinal changes in hubs and topological properties at the modular level after SCI and treatment. We analyzed differences in FC and nodal metrics reflecting modular interaction to investigate brain reorganization after SCI-induced compensation and neurotrophin-3 (NT3)–chitosan-induced regeneration. Mean inter-modular FC and participation coefficient of areas related to motor coordination were significantly higher in the treatment animals than in the SCI-only ones at the late stage. The magnocellular part of the red nucleus may reflect the best difference in brain reorganization after SCI and therapy. Treatment can enhance information flows between regions and promote the integration of motor functions to return to normal. These findings may reveal the information processing of disrupted network modules.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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