Nature Communications (Sep 2017)
Identification of HSP90 inhibitors as a novel class of senolytics
- Heike Fuhrmann-Stroissnigg,
- Yuan Yuan Ling,
- Jing Zhao,
- Sara J. McGowan,
- Yi Zhu,
- Robert W. Brooks,
- Diego Grassi,
- Siobhan Q. Gregg,
- Jennifer L. Stripay,
- Akaitz Dorronsoro,
- Lana Corbo,
- Priscilla Tang,
- Christina Bukata,
- Nadja Ring,
- Mauro Giacca,
- Xuesen Li,
- Tamara Tchkonia,
- James L. Kirkland,
- Laura J. Niedernhofer,
- Paul D. Robbins
Affiliations
- Heike Fuhrmann-Stroissnigg
- Department of Metabolism and Aging, The Scripps Research Institute
- Yuan Yuan Ling
- Department of Metabolism and Aging, The Scripps Research Institute
- Jing Zhao
- Department of Metabolism and Aging, The Scripps Research Institute
- Sara J. McGowan
- Department of Metabolism and Aging, The Scripps Research Institute
- Yi Zhu
- University of Pittsburgh School of Medicine
- Robert W. Brooks
- Department of Metabolism and Aging, The Scripps Research Institute
- Diego Grassi
- Department of Metabolism and Aging, The Scripps Research Institute
- Siobhan Q. Gregg
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Jennifer L. Stripay
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Akaitz Dorronsoro
- Department of Metabolism and Aging, The Scripps Research Institute
- Lana Corbo
- Department of Metabolism and Aging, The Scripps Research Institute
- Priscilla Tang
- Department of Metabolism and Aging, The Scripps Research Institute
- Christina Bukata
- Department of Metabolism and Aging, The Scripps Research Institute
- Nadja Ring
- International Centre for Genetic Engineering and Biotechnology
- Mauro Giacca
- International Centre for Genetic Engineering and Biotechnology
- Xuesen Li
- Department of Metabolism and Aging, The Scripps Research Institute
- Tamara Tchkonia
- University of Pittsburgh School of Medicine
- James L. Kirkland
- University of Pittsburgh School of Medicine
- Laura J. Niedernhofer
- Department of Metabolism and Aging, The Scripps Research Institute
- Paul D. Robbins
- Department of Metabolism and Aging, The Scripps Research Institute
- DOI
- https://doi.org/10.1038/s41467-017-00314-z
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
The accumulation of senescent cells is thought to contribute to the age-associated decline in tissue function. Here, the authors identify HSP90 inhibitors as a new class of senolytic compounds in an in vitro screening and show that administration of a HSP90 inhibitor reduces age-related symptoms in progeroid mice.
