Preparation, Characterization and Evaluation Biological Activity of Cobalt (II) with Mixed Ligands complexes

Abstract

New cobalt (II) complexes with mixed ligands including [(2- oxime-4-hydrazone) pentane (L1H) and 2-chlorobenzaldehyde thiosemicarbazone(T1H) ,or 3,4-dimethoxy acetophenone thiosemicarbazone (T2H); glycine (GH) or metformin (mf)] have been prepared in both pH (6.5-7) and (9.5-10) using classical and microwave techniques. The resulting complexes have been characterized using physio- chemical and spectral techniques. The study suggested that the complexes have the generalformulate [Co(L1H)(TH)(BH)](CH3COO)2and[Co(L1)(TH)(G)]or[Co(L1)(T)(mf)] at pH (6.5-7) and (9.5- 10), respectively {where TH= T1H or T2H; T= deprotonated T1H or T2H; L1H=L1=deprotenated; BH= GH or mf; G= deprotonated GH]. Hexacoordinated mononuclear complexes having distorted octahedral geometries have been investigated. The biologicall activity of the ligands and complexes have been evaluated by agar plate diffusion technique against Echerichia coli, Klipsila pnnemoia, Staphylococcus aureus and Pseudomonas aeruginosa. Some compounds have been found to have antibacterial activity.

Keywords

• mixed ligands
• cobalt (ii) complexes
• thiosemicarbazone
• metformin glycine