Nature Communications (May 2022)

The dopamine transporter antiports potassium to increase the uptake of dopamine

  • Solveig G. Schmidt,
  • Mette Galsgaard Malle,
  • Anne Kathrine Nielsen,
  • Søren S.-R. Bohr,
  • Ciara F. Pugh,
  • Jeppe C. Nielsen,
  • Ida H. Poulsen,
  • Kasper D. Rand,
  • Nikos S. Hatzakis,
  • Claus J. Loland

DOI
https://doi.org/10.1038/s41467-022-30154-5
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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The dopamine transporter, DAT, controls dopamine signaling by facilitating its reuptake using the Na+ gradient as driving force. Here, the authors uncover that an antiport of K+ ions also contributes to setting the rate of DAT-mediated dopamine clearance.