Povidone-iodine effect on the eradication of highly oncogenic HPV types in women with lesions in the uterine cervix

Abstract

Povidone-iodine effect on the eradication of highly oncogenic HPV types in women with lesions in the uterine cervix S.O. Dubovina1, L.V. Krasilnikova2, O.A. Ardintseva1, M.V. Varicheva3, N.S. Tsircunova4, O.A. Afrikyan1, P.N. Afanasova1, N.B. Gadzhibekova5 1 Rostov State Medical University, Rostov-on-Don, Russian Federation 2 LLC «DAVINCI GROUP», Rostov-on-Don, Russian Federation 3 Rostov-on-Don City Hospital No. 20, Rostov-on-Don, Russian Federation 4 Rostov-on-Don City Hospital No. 6, Rostov-on-Don, Russian Federation 5 City Emergency Hospital, Taganrog, Russian Federation The article discusses the actual problem associated with human papillomavirus (HPV) of diseases of the uterine cervix in the reproductive age. Cervical cancer (CC) is the third most common gynecological cancer. At the present, there is a tendency to its rejuvenation. Each year, about 500,000 new cases of cervical cancer are detected worldwide, 90% of which occurs in developing countries. According to the WHO, in 2015 in Russia, 16710 new cases of cervical cancer were registered. 6,628 patients died from the progression of the malignant process of this localization in 2015. The incidence rate in 2015 was 15.1 per 100 thousand population. More than 100 HPV genotypes have been identified in the female reproductive tract. 13 types of HPV are recognized as high oncogenic (13HR), causing cancer. Considering the increase in the incidence of CC, options for management of patients with papilloma viral infection are observed. An analysis of the effectiveness of povidone-iodine in the comprehensive treatment of papilloma viral lesions of the mucous membrane of the vagina and uterine cervix was carried out. Povidone-iodine, widely used in clinical practice as an antiseptic, has been shown to have cytotoxic effects. Besides, povidone-iodine significantly suppresses cell proliferation at a low concentration corresponding to 20 μM I2. Experiments with fresh samples of human blood have shown that the antiproliferative activity of povidone-iodine is preserved in a high degree of blood plasma. These data indicate that povidone-iodine can be a potent agent for use in the development of anti-tumor tactics. Key words: cervical cancer, papilloma viral infection, antiviral effect, povidone-iodine, Betadine. For citation: Dubovina S.O., Krasilnikova L.V., Ardintseva O.A. et al. Povidone-iodine effect on the eradication of highly oncogenic HPV types in women with lesions in the uterine cervix. Russian Journal of Woman and Child Health. 2018;1(2):156–161.