Evaluation of Shonitasthapana karma of Yashtimadhu (Glycyrrhiza glabra linn.): An experimental study

Abstract

Introduction: Many pharmacological actions have been mentioned in Ayurveda literature. However, there is no equality in understanding of these actions because of different commentator's view, so this study has been planned to reevaluate one such type of pharmacological action, shonita sthapana by an experimental method by seeing the effect of yashtimadhu on various blood parameters and coagulation profile in normal albino Wistar rats and Swiss albino mice. Methods: This study was conducted in two parts. The first experiment was done to evaluate the effect of madhuka on 18 normal albino Wistar rats by dividing three groups of 6 rats and giving carboxymethylcellulose (CMC) solution, 360 mg/kg madhuka powder, and 180 mg/kg madhuka powder, respectively. The second experiment was done to evaluate the effect of madhuka in 18 swiss albino mice by dividing them in three groups of 6 mice and giving CMC solution, 360 mg/kg madhuka powder and 180 mg/kg madhuka powder, respectively, for 23 days and aspirin at 600 mg/kg b.w. for last 7 days along with vehicle and drug. Different hematology analysis and coagulation profile were evaluated. Results: There is no any significant result was found for any parameter in the experiment. Conclusion: Yashtimadhu is not having any effect on blood parameters and coagulation profile in present experimental model.

Keywords

• blood components/parameters
• coagulation
• experimental study
• glycyrrhiza glabra linn
• shonita-sthapana karma
• yashtimadhu