Терапевтический архив (Sep 2013)

Endothelial NO synthase and connexin 37 gene polymorphisms as a risk factor for myocardial infarction in subjects without a history of coronary artery disease

  • A V Balatskiĭ,
  • E Iu Andreenko,
  • L M Samokhodskaia,
  • S A Boĭtsov,
  • V A Tkachuk

Journal volume & issue
Vol. 85, no. 9
pp. 18 – 22

Abstract

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Aim. To define a role of connexin37 (Cx37) C1019T and endothelial nitric oxide synthase (eNOS) G894T polymorphisms in the development of myocardial infarction (MI) in subjects without a history of coronary artery disease. Subjects and results. The investigation enrolled 183 male patients, of whom 56 (18.1%) developed MI in the presence of clinically and instrumentally verified coronary heart disease (CHD) (except MI) and 127 (81.9%) patients did without any previous clinical signs of CHD. The gene polymorphisms were identified using polymerase chain reaction and restriction fragment length polymorphism analysis. Results. The spread of the G allele in the eNOS gene was 59.8% in the patients with MI in the presence of CHD and 75.6% in those with MI without a history of coronary artery disease (p

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