International Journal of Infectious Diseases (Jan 2022)

Detection and sequencing of Zika virus in normocephalic newborns with congenital Zika infection

  • Breno Lima de Almeida,
  • Marta Giovanetti,
  • João Vitor Oliveira,
  • Tereza Cristina Xavier Carvalho,
  • Eduardo Manoel Figueiredo,
  • Rosana Pellegrini,
  • Juan Ignacio Calcagno,
  • Marcia Weber Carneiro,
  • Juliana M.G.C. de Oliveira,
  • Adriana Virgínia Barros Faiçal,
  • Iluska Andrade Agra,
  • Cristina Salles,
  • Emília Katiane Embiruçu de Araújo Leão,
  • Rita Lucena,
  • Angelina X. Acosta,
  • Luiz Carlos Junior Alcantara,
  • Isadora Cristina de Siqueira

Journal volume & issue
Vol. 114
pp. 128 – 131

Abstract

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ABSTRACT: Fourteen asymptomatic normocephalic newborns with confirmed congenital Zika infection were investigated. All newborns presented Zika virus (ZIKV) positivity on reverse transcriptase polymerase chain reaction. Following ZIKV-specific NS5 gene fragment sequencing in one child, phylogenetic analysis revealed that this isolate belonged to the Asian genotype, and clustered closely with other sequences previously isolated in north-east and northern regions of Brazil.

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