International Journal of Infectious Diseases (Sep 2022)
TNF-related apoptosis-inducing ligand, interferon gamma-induced protein 10, and C-reactive protein in predicting the progression of SARS-CoV-2 infection: a prospective cohort study
- Sina A. Tegethoff,
- Guy Danziger,
- Dennis Kühn,
- Charlotte Kimmer,
- Thomas Adams,
- Lena Heintz,
- Carlos Metz,
- Katharina Reifenrath,
- Rebecca Angresius,
- Sebastian Mang,
- Torben Rixecker,
- André Becker,
- Jürgen Geisel,
- Christophe Jentgen,
- Frederik Seiler,
- Matthias C. Reichert,
- Franziska Fröhlich,
- Sascha Meyer,
- Jürgen Rissland,
- Sebastian Ewen,
- Gudrun Wagenpfeil,
- Katharina Last,
- Sigrun Smola,
- Robert Bals,
- Frank Lammert,
- Sören L. Becker,
- Marcin Krawczyk,
- Philipp M. Lepper,
- Cihan Papan
Affiliations
- Sina A. Tegethoff
- Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany
- Guy Danziger
- Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Dennis Kühn
- Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany; Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Charlotte Kimmer
- Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany
- Thomas Adams
- Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Lena Heintz
- Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Carlos Metz
- Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Katharina Reifenrath
- Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany; Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Rebecca Angresius
- Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Sebastian Mang
- Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Torben Rixecker
- Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany
- André Becker
- Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Jürgen Geisel
- Department of Clinical Chemistry and Laboratory Medicine, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Christophe Jentgen
- Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Frederik Seiler
- Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Matthias C. Reichert
- Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Franziska Fröhlich
- Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany; Department of General Paediatrics and Neonatology, Saarland University, Homburg, Germany
- Sascha Meyer
- Department of General Paediatrics and Neonatology, Saarland University, Homburg, Germany
- Jürgen Rissland
- Centre for Infectious Diseases, Institute of Virology, Saarland University Medical Centre, Homburg, Germany
- Sebastian Ewen
- Department of Emergency Medicine, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Gudrun Wagenpfeil
- Institute of Medical Biometry, Epidemiology and Medical Informatics, Saarland University, Homburg, Germany
- Katharina Last
- Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany
- Sigrun Smola
- Centre for Infectious Diseases, Institute of Virology, Saarland University Medical Centre, Homburg, Germany; Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, Saarland University Campus, Saarbrücken, Germany
- Robert Bals
- Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Frank Lammert
- Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany; Hannover Medical School (MHH), Hannover, Germany
- Sören L. Becker
- Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany
- Marcin Krawczyk
- Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Philipp M. Lepper
- Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany
- Cihan Papan
- Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany; Corresponding author: Cihan Papan, MD, Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Kirrberger Strasse, Building 43, Homburg, Germany.
- Journal volume & issue
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Vol. 122
pp. 178 – 187
Abstract
ABSTRACT: Background: Early prognostication of COVID-19 severity will potentially improve patient care. Biomarkers, such as TNF-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein 10 (IP-10), and C-reactive protein (CRP), might represent possible tools for point-of-care testing and severity prediction. Methods: In this prospective cohort study, we analyzed serum levels of TRAIL, IP-10, and CRP in patients with COVID-19, compared them with control subjects, and investigated the association with disease severity. Results: A total of 899 measurements were performed in 132 patients (mean age 64 years, 40.2% females). Among patients with COVID-19, TRAIL levels were lower (49.5 vs 87 pg/ml, P = 0.0142), whereas IP-10 and CRP showed higher levels (667.5 vs 127 pg/ml, P <0.001; 75.3 vs 1.6 mg/l, P <0.001) than healthy controls. TRAIL yielded an inverse correlation with length of hospital and intensive care unit (ICU) stay, Simplified Acute Physiology Score II, and National Early Warning Score, and IP-10 showed a positive correlation with disease severity. Multivariable regression revealed that obesity (adjusted odds ratio [aOR] 5.434, 95% confidence interval [CI] 1.005-29.38), CRP (aOR 1.014, 95% CI 1.002-1.027), and peak IP-10 (aOR 1.001, 95% CI 1.00-1.002) were independent predictors of in-ICU mortality. Conclusions: We demonstrated a correlation between COVID-19 severity and TRAIL, IP-10, and CRP. Multivariable regression showed a role for IP-10 in predicting unfavourable outcomes, such as in-ICU mortality. Trial registration: Clinicaltrials.gov, NCT04655521
