Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence

Stefanie R. Bailey; Michelle H. Nelson; Kinga Majchrzak; Jacob S. Bowers; Megan M. Wyatt; Aubrey S. Smith; Lillian R. Neal; Keisuke Shirai; Carmine Carpenito; Carl H. June; Michael J. Zilliox; Chrystal M. Paulos

doi:10.1038/s41467-017-01867-9

Nature Communications (Dec 2017)

Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence

Stefanie R. Bailey,
Michelle H. Nelson,
Kinga Majchrzak,
Jacob S. Bowers,
Megan M. Wyatt,
Aubrey S. Smith,
Lillian R. Neal,
Keisuke Shirai,
Carmine Carpenito,
Carl H. June,
Michael J. Zilliox,
Chrystal M. Paulos

Affiliations

Stefanie R. Bailey: Department of Microbiology and Immunology, Medical University of South Carolina
Michelle H. Nelson: Department of Microbiology and Immunology, Medical University of South Carolina
Kinga Majchrzak: Department of Microbiology and Immunology, Medical University of South Carolina
Jacob S. Bowers: Department of Microbiology and Immunology, Medical University of South Carolina
Megan M. Wyatt: Department of Microbiology and Immunology, Medical University of South Carolina
Aubrey S. Smith: Department of Microbiology and Immunology, Medical University of South Carolina
Lillian R. Neal: Department of Microbiology and Immunology, Medical University of South Carolina
Keisuke Shirai: Hematology/Oncology Division, Hollings Cancer Center, Medical University of South Carolina
Carmine Carpenito: Department of Pathology and Laboratory Medicine, University of Pennsylvania Cancer Center
Carl H. June: Department of Pathology and Laboratory Medicine, University of Pennsylvania Cancer Center
Michael J. Zilliox: Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago
Chrystal M. Paulos: Department of Microbiology and Immunology, Medical University of South Carolina

DOI: https://doi.org/10.1038/s41467-017-01867-9
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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The role of human CD4+ T cell subsets in cancer immunotherapy is still unclear. Here, the authors show that CD26 identifies three CD4+ T cell subsets with distinct immunological properties in both healthy individuals and cancer patients.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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