Nature Communications (Apr 2016)

CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection

  • Ming Zeng,
  • Laifeng Ren,
  • Ken'Ichi Mizuno,
  • Konstantinos Nestoras,
  • Haibin Wang,
  • Zizhi Tang,
  • Liandi Guo,
  • Daochun Kong,
  • Qiwen Hu,
  • Qun He,
  • Lilin Du,
  • Antony M. Carr,
  • Cong Liu

DOI
https://doi.org/10.1038/ncomms11364
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

Read online

The repair of double-strand DNA breaks by homologous recombination requires resection of the DNA ends. Here the authors show that in Schizosaccharomyces pombe and human cells, Wdr70 is recruited as part of the CRL4 complex to promote ubiquitination of H2B and allow Exo1-mediated resection.