AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice

Abstract

Ericsson et al. show in aged mice that the panAMPK activator O304 prevents and reverts age-associated hyperinsulinemia and insulin resistance, as well as improving cardiac function and exercise capacity. O304 thus functions as an exercise mimetic and could therefore have a similar therapeutic potential in aged humans and improve quality of life.