Haematologica (Aug 2010)

Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complex

  • Marco Gabbianelli,
  • Ugo Testa,
  • Ornella Morsilli,
  • Elvira Pelosi,
  • Ernestina Saulle,
  • Eleonora Petrucci,
  • Germana Castelli,
  • Serena Giovinazzi,
  • Gualtiero Mariani,
  • Micol E. Fiori,
  • Giuseppina Bonanno,
  • Adriana Massa,
  • Carlo M. Croce,
  • Laura Fontana,
  • Cesare Peschle

DOI
https://doi.org/10.3324/haematol.2009.018259
Journal volume & issue
Vol. 95, no. 8

Abstract

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Background The human hemoglobin switch (HbF→HbA) takes place in the peri/post-natal period. In adult life, however, the residual HbF (