Nature Communications (Nov 2017)
Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients
- Julie Jézéquel,
- Emily M. Johansson,
- Julien P. Dupuis,
- Véronique Rogemond,
- Hélène Gréa,
- Blanka Kellermayer,
- Nora Hamdani,
- Emmanuel Le Guen,
- Corentin Rabu,
- Marilyn Lepleux,
- Marianna Spatola,
- Elodie Mathias,
- Delphine Bouchet,
- Amy J. Ramsey,
- Robert H. Yolken,
- Ryad Tamouza,
- Josep Dalmau,
- Jérôme Honnorat,
- Marion Leboyer,
- Laurent Groc
Affiliations
- Julie Jézéquel
- Univ. de Bordeaux, Interdisciplinary Institute for Neuroscience
- Emily M. Johansson
- Univ. de Bordeaux, Interdisciplinary Institute for Neuroscience
- Julien P. Dupuis
- Univ. de Bordeaux, Interdisciplinary Institute for Neuroscience
- Véronique Rogemond
- Institut NeuroMyoGene INSERM U1217/CNRS
- Hélène Gréa
- Univ. de Bordeaux, Interdisciplinary Institute for Neuroscience
- Blanka Kellermayer
- Univ. de Bordeaux, Interdisciplinary Institute for Neuroscience
- Nora Hamdani
- University Paris Est Créteil, Psychiatry department, Hopitaux Universitaires Henri Mondor, AP-HP, DHU PePSY
- Emmanuel Le Guen
- University Paris Est Créteil, Psychiatry department, Hopitaux Universitaires Henri Mondor, AP-HP, DHU PePSY
- Corentin Rabu
- University Paris Est Créteil, Psychiatry department, Hopitaux Universitaires Henri Mondor, AP-HP, DHU PePSY
- Marilyn Lepleux
- Univ. de Bordeaux, Interdisciplinary Institute for Neuroscience
- Marianna Spatola
- Biomedical Research Institute August Pi i Sunyer (IDIBAPS), University of Barcelona, Catalan Institution for Research and Advanced Studies (ICREA)
- Elodie Mathias
- Institut NeuroMyoGene INSERM U1217/CNRS
- Delphine Bouchet
- Univ. de Bordeaux, Interdisciplinary Institute for Neuroscience
- Amy J. Ramsey
- Department of Physiology, Department of Pharmacology and Toxicology, University of Toronto
- Robert H. Yolken
- The Johns Hopkins University School of Medicine, Stanley Division of Developmental Neurovirology
- Ryad Tamouza
- INSERM, U1160, Hôpital Saint Louis
- Josep Dalmau
- Biomedical Research Institute August Pi i Sunyer (IDIBAPS), University of Barcelona, Catalan Institution for Research and Advanced Studies (ICREA)
- Jérôme Honnorat
- Institut NeuroMyoGene INSERM U1217/CNRS
- Marion Leboyer
- University Paris Est Créteil, Psychiatry department, Hopitaux Universitaires Henri Mondor, AP-HP, DHU PePSY
- Laurent Groc
- Univ. de Bordeaux, Interdisciplinary Institute for Neuroscience
- DOI
- https://doi.org/10.1038/s41467-017-01700-3
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Autoantibodies are found in neuropsychiatric conditions but without clear cellular mechanism and disease relevance. This study shows higher prevalence of autoantibodies against NMDAR receptors in schizophrenia patients, and patient-associated antibody can alter synaptic receptor trafficking and plasticity.
