Whole-genome sequencing analysis of the cardiometabolic proteome

Arthur Gilly; Young-Chan Park; Grace Png; Andrei Barysenka; Iris Fischer; Thea Bjørnland; Lorraine Southam; Daniel Suveges; Sonja Neumeyer; N. William Rayner; Emmanouil Tsafantakis; Maria Karaleftheri; George Dedoussis; Eleftheria Zeggini

doi:10.1038/s41467-020-20079-2

Nature Communications (Dec 2020)

Whole-genome sequencing analysis of the cardiometabolic proteome

Arthur Gilly,
Young-Chan Park,
Grace Png,
Andrei Barysenka,
Iris Fischer,
Thea Bjørnland,
Lorraine Southam,
Daniel Suveges,
Sonja Neumeyer,
N. William Rayner,
Emmanouil Tsafantakis,
Maria Karaleftheri,
George Dedoussis,
Eleftheria Zeggini

Affiliations

Arthur Gilly: Institute of Translational Genomics, Helmholtz Zentrum München—German Research Center for Environmental Health
Young-Chan Park: Wellcome Sanger Institute, Wellcome Genome Campus
Grace Png: Institute of Translational Genomics, Helmholtz Zentrum München—German Research Center for Environmental Health
Andrei Barysenka: Institute of Translational Genomics, Helmholtz Zentrum München—German Research Center for Environmental Health
Iris Fischer: Institute of Translational Genomics, Helmholtz Zentrum München—German Research Center for Environmental Health
Thea Bjørnland: Wellcome Sanger Institute, Wellcome Genome Campus
Lorraine Southam: Institute of Translational Genomics, Helmholtz Zentrum München—German Research Center for Environmental Health
Daniel Suveges: Wellcome Sanger Institute, Wellcome Genome Campus
Sonja Neumeyer: Institute of Translational Genomics, Helmholtz Zentrum München—German Research Center for Environmental Health
N. William Rayner: Institute of Translational Genomics, Helmholtz Zentrum München—German Research Center for Environmental Health
Emmanouil Tsafantakis: Anogia Medical Centre
Maria Karaleftheri: Echinos Medical Centre
George Dedoussis: Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens
Eleftheria Zeggini: Institute of Translational Genomics, Helmholtz Zentrum München—German Research Center for Environmental Health

DOI: https://doi.org/10.1038/s41467-020-20079-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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The human proteome represents a crucial link between complex disease and genetic/environmental factors. Here, the authors investigate 257 cardiometabolic-relevant protein biomarkers in whole genome sequencing data from 1328 individuals, revealing the genetic architecture underlying biomarker variation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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