Nature Communications (Sep 2018)
Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections
- Zhuobin Xu,
- Zhiyue Qiu,
- Qi Liu,
- Yixin Huang,
- Dandan Li,
- Xinggui Shen,
- Kelong Fan,
- Juqun Xi,
- Yunhao Gu,
- Yan Tang,
- Jing Jiang,
- Jialei Xu,
- Jinzhi He,
- Xingfa Gao,
- Yuan Liu,
- Hyun Koo,
- Xiyun Yan,
- Lizeng Gao
Affiliations
- Zhuobin Xu
- Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University
- Zhiyue Qiu
- Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University
- Qi Liu
- Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University
- Yixin Huang
- Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University
- Dandan Li
- Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University
- Xinggui Shen
- Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center
- Kelong Fan
- Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences
- Juqun Xi
- Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University
- Yunhao Gu
- Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University
- Yan Tang
- Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University
- Jing Jiang
- Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University
- Jialei Xu
- State Key Laboratory of Oral Diseases, Department of Endodontics, West China Hospital of Stomatoloty, Sichuan University
- Jinzhi He
- State Key Laboratory of Oral Diseases, Department of Endodontics, West China Hospital of Stomatoloty, Sichuan University
- Xingfa Gao
- College of Chemistry and Chemical Engineering, Jiangxi Normal University
- Yuan Liu
- Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania
- Hyun Koo
- Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania
- Xiyun Yan
- Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences
- Lizeng Gao
- Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University
- DOI
- https://doi.org/10.1038/s41467-018-06164-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Garlic has a mild antibacterial activity due to its organosulfur content. Here, the authors develop an approach to convert natural organosulfur into iron-sulfur nanosheets, with significantly higher antibacterial activity that can be used against infections as well as biofilms.
