Cell-free fetal DNA testing and its correlation with prenatal indications

Abstract

Highlights The whole-genome sequencing of cell-free fetal DNA from maternal plasma is an effective prenatal screening tool for pregnancies with various prenatal indications. The concentration of cffDNA was linear with gestational age and the Z-score values of the positive NIPT group. NIPT has a significant positive predictive value for pregnancies with prenatal indications.

Keywords

• cffDNA
• Prenatal screening
• Aneuploidy
• Prenatal diagnosis
• Whole-genome sequencing
• Chromosomal abnormalities