Technological strategies for the preparation of lipid nanoparticles: an updated review

Abstract

The concept of improving drug biopharmaceutical properties by proper selection of delivery system should begin with a rational choice of relevant dosage form, followed by the precise assessment of physicochemical compatibility between the drug delivery system (DDS) and the active pharmaceutical ingredient (API). Afterwards, according to laboratory availabilities, an efficient production method should be selected and, if possible, to take into account the opportunity for lab-upscale and prevailed industry research needs. Amid the vast diversity of nanostructured drug delivery carriers, lipid nanoparticles (LNs) stand out with their undeniable advantages like exceptive biocompatibility and multiplicity, and their importance as “green” derivatives for biochemical processes. Their distinctive structural properties also allow adequate protection of loaded APIs against chemical degradation in an aggressive biological environment and provide excellent resiliency in modifying drug release profiles. This review highlights different findings reported by the researchers worldwide over the years and focuses on the various production strategies and techniques for the preparation of LNs.