Nature Communications (Nov 2018)

Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex

  • Khadeejah T. Sultan,
  • Wenying Angela Liu,
  • Zhao-Lu Li,
  • Zhongfu Shen,
  • Zhizhong Li,
  • Xin-Jun Zhang,
  • Owen Dean,
  • Jian Ma,
  • Song-Hai Shi

DOI
https://doi.org/10.1038/s41467-018-07055-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Diverse GABAergic neurons arise from progenitors in the medial ganglionic eminence. Here, the authors show these progenitors are progressively fate-restricted, with early-born interneurons occupying cortex in an “inside-out” pattern and later-born types like chandelier cells generated “outside-in”.