Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability

• Ingrid Grunert,
• Katrin Heinrich,
• Juliane Ernst,
• Michael Hingar,
• Alexandre Briguet,
• Michael Leiss,
• Manfred Wuhrer,
• Dietmar Reusch,
• Patrick Bulau

Affiliations

Ingrid Grunert

Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, Germany

Katrin Heinrich

Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, Germany

Juliane Ernst

Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, Germany

Michael Hingar

Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, Germany

Alexandre Briguet

Pharma Technical Development, Hoffmann-La Roche, Basel, Switzerland

Michael Leiss

Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, Germany

Manfred Wuhrer

Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

Dietmar Reusch

Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, Germany

Patrick Bulau

Pharma Technical Development, Hoffmann-La Roche, Basel, Switzerland