Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice

Zhengyi Zhang; An-Chieh Feng; David Salisbury; Xin Liu; Xiaohui Wu; Jason Kim; Irina Lapina; Dan Wang; Brennan Lee; Josue Fraga; Calvin Pan; Kevin J. Williams; Aldons J. Lusis; Phil Scumpia; Tamer Sallam

doi:10.1038/s41467-020-14711-4

Nature Communications (Feb 2020)

Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice

Zhengyi Zhang,
An-Chieh Feng,
David Salisbury,
Xin Liu,
Xiaohui Wu,
Jason Kim,
Irina Lapina,
Dan Wang,
Brennan Lee,
Josue Fraga,
Calvin Pan,
Kevin J. Williams,
Aldons J. Lusis,
Phil Scumpia,
Tamer Sallam

Affiliations

Zhengyi Zhang: Division of Cardiology, Department of Medicine, University of California
An-Chieh Feng: Molecular Biology Interdepartmental Doctoral Program, University of California
David Salisbury: Division of Cardiology, Department of Medicine, University of California
Xin Liu: Molecular Biology Interdepartmental Doctoral Program, University of California
Xiaohui Wu: Division of Cardiology, Department of Medicine, University of California
Jason Kim: Division of Cardiology, Department of Medicine, University of California
Irina Lapina: Division of Cardiology, Department of Medicine, University of California
Dan Wang: Division of Cardiology, Department of Medicine, University of California
Brennan Lee: Division of Cardiology, Department of Medicine, University of California
Josue Fraga: Division of Cardiology, Department of Medicine, University of California
Calvin Pan: Division of Cardiology, Department of Medicine, University of California
Kevin J. Williams: Department of Biological Chemistry, University of California
Aldons J. Lusis: Division of Cardiology, Department of Medicine, University of California
Phil Scumpia: Division of Dermatology, Department of Medicine, University of California
Tamer Sallam: Division of Cardiology, Department of Medicine, University of California

DOI: https://doi.org/10.1038/s41467-020-14711-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the biogenesis, localization and transport of RNA. Here authors investigate a role for hnRNPs in sterol metabolism in mice and provide insights into their role in selective promoter activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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