Química Nova (Apr 2014)

Constituintes químicos das cascas do caule de Vochysia thyrsoidea Pohl. (Vochysiaceae) e avaliação das atividades citotóxica e inibitória frente as catepsinas B e K

  • Lorena Ramos Freitas de Sousa,
  • Jame's A. da Silva,
  • Paulo Cezar Vieira,
  • Maísa Borges Costa,
  • Mirley Luciene dos Santos,
  • Aline Borba Sbardelotto,
  • Cláudia do Ó Pessoa,
  • Manoel Odorico de Moraes,
  • Antônio Carlos Severo Menezes

DOI
https://doi.org/10.5935/0100-4042.20140049
Journal volume & issue
Vol. 37, no. 2
pp. 281 – 287

Abstract

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A new flavonoid, catechin-3-O-(3"-O-trans-cinnamoyl)-α-rhamnopyranoside, along with known compounds, catechin-3-O-α-rhamnopyranoside, 3-oxo-urs-12-en-28-oic acid, 2,4,6-trimethoxybenzoic acid, 2-butyl-D-fructofuranoside and 1-butyl-D-fructofuranoside, has been isolated from the stem bark of V. thyrsoidea. These compounds were assayed for inhibition of protease activity (cathepsins B and K) and against cancer cell lines. Catechin-3-O-(3"-O-trans-cinnamoyl)-α-rhamnopyranoside showed moderate inhibitory activity (IC50 = 62.02 µM) against cathepsin B while 2-butyl-D-fructofuranoside was the most potent against a strain of CNS (SF-295) and human leukemia (HL-60) with IC50 = 36.80 µM and IC50 = 25.37 µM, respectively.

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