Nature Communications (Jan 2023)
Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation
- Xinwei Liu,
- Yingying Ye,
- Liling Zhu,
- Xiaoyun Xiao,
- Boxuan Zhou,
- Yuanting Gu,
- Hang Si,
- Huixin Liang,
- Mingzhu Liu,
- Jiaqian Li,
- Qiongchao Jiang,
- Jiang Li,
- Shubin Yu,
- Ruiying Ma,
- Shicheng Su,
- Jian-You Liao,
- Qiyi Zhao
Affiliations
- Xinwei Liu
- Department of Infectious Diseases, Third Affiliated Hospital, Sun Yat-Sen University
- Yingying Ye
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Liling Zhu
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Xiaoyun Xiao
- Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Boxuan Zhou
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Yuanting Gu
- Department of Breast Surgery, the First Affiliated Hospital, Zhengzhou University
- Hang Si
- Department of Infectious Diseases, Third Affiliated Hospital, Sun Yat-Sen University
- Huixin Liang
- Department of Infectious Diseases, Third Affiliated Hospital, Sun Yat-Sen University
- Mingzhu Liu
- Department of Infectious Diseases, Third Affiliated Hospital, Sun Yat-Sen University
- Jiaqian Li
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Qiongchao Jiang
- Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Jiang Li
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Shubin Yu
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Ruiying Ma
- Department of Infectious Diseases, Third Affiliated Hospital, Sun Yat-Sen University
- Shicheng Su
- Department of Infectious Diseases, Third Affiliated Hospital, Sun Yat-Sen University
- Jian-You Liao
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Qiyi Zhao
- Department of Infectious Diseases, Third Affiliated Hospital, Sun Yat-Sen University
- DOI
- https://doi.org/10.1038/s41467-023-35856-y
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
Stromal cells in the tumour microenvironment are reported to regulate cancer stemness via biomechanical signals. Here the authors show that TAZ activated by biomechanical cues enhanced cancer stem cell properties via phase separation with Nanog.
