Stretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation

Abstract

Chiral pyrazolone derivatives show promising biological activity in commercial drugs. Here, the authors report an enantioselective allenylation of pyrazolones by fine tuning of Trost’s ligands, which leads to a chiral pocket featuring high efficiency and asymmetric induction in the catalytic process.