<i>tert</i>-Butyl 2-Amino-3-cyano-5-oxo-4-phenyl-5,7-dihydropyrano[2,3-<i>c</i>]pyrrole-6(4<i>H</i>)-carboxylate

Abstract

Organocatalyzed synthesis of tert-butyl 2-amino-3-cyano-5-oxo-4-phenyl-5,7-dihydropyrano[2,3-c]pyrrole-6(4H)-carboxylate, prepared from Boc-tetramic acid and benzylidenemalononitrile, is disclosed. Two bifunctional noncovalent organocatalysts were employed, yielding the product as a racemic mixture in both cases. The structure of the new synthesized compound was confirmed by high resolution mass-spectrometry, 1H- and 13C-NMR, HSQC, and IR spectroscopy.

Keywords

• bifunctional noncovalent organocatalysts
• tetramic acids
• Michael addition
• pyrano[2,3-<i>c</i>]pyrrole
• benzylidenemalononitrile