Chronic kidney disease in hypertensive subjects ≥60 years treated in Primary Care

Abstract

Background: Hypertension (HT) is the second leading cause of kidney failure. In hypertensive patients with chronic kidney disease (CKD), blood pressure (BP) control is the most important intervention to minimise progression. For CKD diagnosis, standardised creatinine and estimated glomerular filtration rate (eGFR) testing by CKD-EPI is recommended. Objectives: To describe the prevalence and factors associated with a moderate decrease in eGFR (by CKD-EPI) and BP control in subjects with HT. Methods: Cross-sectional descriptive study in subjects ≥60 years included in the SIDIAP plus database with hypertension and standardised serum creatinine and BP tests in the last 2 years. Exclusion criteria: eGFR < 30, dialysis or kidney transplantation, prior cardiovascular disease, home care. Primary endpoint: eGFR by CKD-EPI formula. Covariates: demographic data, examination, cardiovascular risk factors, heart failure and auricular fibrillation diagnosis, and drugs (antihypertensive agents acting on renal function, antiplatelet and lipid lowering agents). BP control criteria: ≤130/80 mmHg in individuals with albuminuria, ≤140/90 in all other subjects. Results: Prevalence of eGFR <60 = 18.8%. Associated factors: age, gender, heart failure, albumin/creatinine ratio, auricular fibrillation, smoking, dyslipidaemia, diabetes and obesity. BP control: 66.14 and 63.24% in eGFR ≥ 60 and eGFR < 60, respectively (p < 0.05). Exposure to drugs was higher in eGFR < 60. Conclusion: One in 5 hypertensive patients without cardiovascular disease ≥60 years in primary care presented with a moderate decrease in eGFR. In addition to age and sex, albuminuria and heart failure were the main associated factors. Despite the increased exposure to drugs, BP control was lower in CKD.

Keywords

• Chronic kidney disease
• Hypertension
• Primary Care
• Prevalence
• Risks factors