Research progress on the intervening effects of active components of Chinese herbs on amyloid-beta-induced injury of neural cells

Abstract

Alzheimer's disease is a common clinical central nervous system degenerative disease. From 1906, it has not yet been clearly revealed the pathogenesis, and there are no clinically safe and effective drugs. Amyloid-beta (Aβ) cascade reaction theory is currently recognized as the pathogenesis. Aβ deposition of neurotoxicity is an important part of the pathogenesis. There are Aβ-induced inflammation of the central nervous and oxidative stress-induced apoptosis induced by a variety of ways leading to neuronal dysfunction and death. This article summarizes the active ingredients of traditional Chinese medicine that has a protective effect on Aβ toxicity in recent years. Traditional Chinese medicine mainly through the antiapoptosis, antioxidation, and anti-inflammatory reduces Aβ production and deposition of Aβ on the protection of nerve cell injury.

Keywords

• Alzheimer's disease
• amyloid-beta cascade reaction
• monomer composition
• traditional Chinese medicine
• β-amyloid