NSD2 is a conserved driver of metastatic prostate cancer progression

Alvaro Aytes; Arianna Giacobbe; Antonina Mitrofanova; Katia Ruggero; Joanna Cyrta; Juan Arriaga; Luis Palomero; Sonia Farran-Matas; Mark A. Rubin; Michael M. Shen; Andrea Califano; Cory Abate-Shen

doi:10.1038/s41467-018-07511-4

Nature Communications (Dec 2018)

NSD2 is a conserved driver of metastatic prostate cancer progression

Alvaro Aytes,
Arianna Giacobbe,
Antonina Mitrofanova,
Katia Ruggero,
Joanna Cyrta,
Juan Arriaga,
Luis Palomero,
Sonia Farran-Matas,
Mark A. Rubin,
Michael M. Shen,
Andrea Califano,
Cory Abate-Shen

Affiliations

Alvaro Aytes: Department of Urology, Columbia University Irving Medical Center
Arianna Giacobbe: Department of Urology, Columbia University Irving Medical Center
Antonina Mitrofanova: Department of Systems Biology, Columbia University Irving Medical Center
Katia Ruggero: Programs of Molecular Mechanisms and Experimental Therapeutics in Oncology (ONCOBell), and Cancer Therapeutics Resistance (ProCURE), Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research, L’Hospitalet de Llobregat
Joanna Cyrta: Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
Juan Arriaga: Department of Urology, Columbia University Irving Medical Center
Luis Palomero: Programs of Molecular Mechanisms and Experimental Therapeutics in Oncology (ONCOBell), and Cancer Therapeutics Resistance (ProCURE), Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research, L’Hospitalet de Llobregat
Sonia Farran-Matas: Programs of Molecular Mechanisms and Experimental Therapeutics in Oncology (ONCOBell), and Cancer Therapeutics Resistance (ProCURE), Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research, L’Hospitalet de Llobregat
Mark A. Rubin: Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
Michael M. Shen: Department of Urology, Columbia University Irving Medical Center
Andrea Califano: Department of Systems Biology, Columbia University Irving Medical Center
Cory Abate-Shen: Department of Urology, Columbia University Irving Medical Center

DOI: https://doi.org/10.1038/s41467-018-07511-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Identifying cell intrinsic mechanisms promoting metastasis are necessary to develop new cancer therapeutics. Here they do cross-species computational analysis and identify nuclear receptor binding SET domain Protein 2 (NSD2) as a driver of prostate cancer metastasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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