Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses

Abstract

Following activation, GABAA receptors (GABAARs) undergo desensitization, the impact of which on inhibitory neurotransmission remains unknown. Here the authors describe an enduring form of long-term potentiation at inhibitory synapses that elevates synaptic current amplitude for 24 h following desensitization of GABAARs.