Correlation between the time from rapid eye movement sleep behavior disorder to disease onset and clinical characteristics in Parkinson's disease

Abstract

Objective To study the correlation between the time from rapid eye movement sleep behavior disorder (RBD) to disease onset and the clinical characteristics of Parkinson's disease (PD). Methods A total of 123 PD patients were recruited from Tianjin Huanhu Hospital between September 2019 and December 2021. All participants were divided into the group with RBD (41 cases) and the group without RBD (82 cases) according to the probable RBD criteria. Hoehn ⁃Yahr staging was used to evaluate PD grade. Unified Parkinson's Disease Rating Scale Ⅲ (UPDRS Ⅲ) was used to evaluate the motor function of PD. Mini⁃Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD), Parkinson's Disease Sleep Scale (PDSS), and Non ⁃ Motor Symptom Scale (NMSS) were used to evaluate cognitive function, anxiety, depression, sleep and total non ⁃ motor symptoms. The life quality of patients was evaluated by 39 ⁃ Item Parkinson's Disease Questionnaire (PDQ ⁃ 39). Spearman rank correlation analysis was used to explore the correlation between the time from RBD to disease onset and clinical characteristics in PD. Results UPDRS Ⅲ (t = ⁃ 2.703, P = 0.008) and NMSS (t = ⁃ 2.176, P = 0.032) scores of PD with RBD group were higher than those of the PD without RBD group. The time from the RBD to the onset of PD was posit correlated with NMSS score (rs = 0.547, P = 0.001). Conclusions The motor and non ⁃ motor symptoms in PD patients with RBD are more severe than those of patients without RBD. Early onset of RBD in prodromal period may indicates more severe non⁃motor symptoms in future.

Keywords

• parkinson disease
• rem sleep behavior disorder
• clinical characteristic (not in mesh)